Falseness in the miRNA-Field as an Indicator of Strategic Bias in the Research System via Peer-Review and Publishing Eligibility

Submit Manuscript | http://medcraveonline.com Abbreviations: Deep sequencing: NGS with a high number of replicate reads; GCR8: DiGeorge Syndrome Critical Region 8 Gene; isomiR: The variations of miRNA sequences around the published miRNA sequence at miRBASE, which is misleadingly referred to as gold standard database and due to this a major source of bias the author of this review claims; isomiRs: All similar miRs variations processed from the common genomic loci there can be more than one seed per miR; IsoSeeds: All functional miR-seeds along the miR-or isomiR-strand that are matching with RNA or potentially DNA in canonical or non-canonical ways, via WatsonCrick or non-Watson-Crick base-pairing; KO studies: KnockOut Studies; LOB: Level of Bias; miRNA: microRNAs; miRISC: miRNA-Induced Silencing Complex; miRs: microRNAs; NGS: NextGeneration Sequencing; nt: Nucleotide; OTV: Overall Truth Value; qPCR: Quantitative Polymerase Chain Reaction; RPF: RibosomeProtected mRNA Fragment; RNA: Ribonucleic Acid; RVSA: The Real Value of Scientific Achievement; TNV: True Novelty Value